There is a mounting evidence that oxidatively modified forms of proteins accumulate during oxidative stress. It was found that plasma proteins show different susceptibilities to oxidative modification. The most abundant blood coagulation protein, plasmafibrinogen is much more susceptible to oxidative modification compared to the other major plasma proteins. Fibrinogen plays a central role in controlling hemostasis. The process of thrombus formation involves a large number of subsequent separate eventsthat can occur simultaneously or in series. The first major event that occur are protein adsorption and activation. Fibrinogen seems to play a major role because of its central role in coagulation and its ability to promote blood platelet adhesion andaggregation. Thrombus formation is a surface phenomenon, which is in vivo always initiated upon a surface. This makes optical surface sensing systems very reasonable and promising tools for its monitoring and study. Activated platelets contribute to the
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