This is the main objective of the proposed project to develop new approaches to optical biosensing which will enable rapid and sensitive detection and identification of pathogens in food. The proposed research includes: (i) development of an opticalmultisensor which combines the critical angle refractometry and the surface plasmon resonance (SPR) biosensing method, (b) development of specific bioreceptors for selected pathogens, and (c) development of specific and non-fouling coatings for specificand reference channels of the SPR biosensor. The resulting optical multisensor technology will be evaluated for detection of foodbome bacterial pathogens (Salmonella enteritidis, Listeria monocytogenes, Lagionela) and toxins (Staphylococcus aureusenterotoxinsA and B). This technology can be readily adapted for numerous other applications in which detection of biological substances (drugs, environment pollutants, etc.) in complex samples is needed.
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