The goal of this project is to advance knowledge in the field of photonic nanostructures and biofunctionalizations to enable development of a new generation of surface plasmon resonance (SPR) biosensors for detection of molecular analytes. Research in photonic nanostructures will focus on metal-dielectric structures with localized or guided surface plasmons with potential for SPR sensing. In the area of biofunctionalizations, research effort will concentrate on assemblies of biological and synthetic macromolecules with controlled composition and architecture. The project also encompasses development of novel types of optical biosensors for medical diagnostics, specifically, multichannel biosensors and multifunctional protein chips for new methods of diagnostics of myelodysplastic syndrome, biosensors for diagnostics of herpetic infections, and biosensors for detection of biomarkers of health problems caused by polycyclic aromatic hydrocarbons and endocrine disruptors.
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