New systems for surface modification of biomaterials with improved blood compatibility will be prepared and studied. These systems include defined molecular layers of albumin, organized molecular assemblies of albumin and heparin and thin films of biodegradable amphiphilic bloc copolymers of poly(L-lactic acid) PLA) (PLA-blok-poly(ethylen oxide) and PLA-block-poly(aspartic acid). The structures of these systems may be varied in a defined way and so their contributions to the interaction with the blood environment can be controlled. Molecular layers of immobilized fibrinogen and defined fibrin networks will be studied as models for the assesment of the role of fibrinogen. The systems will be characterized and their interactions with blood will bestudiedusing, besides standard methods, new monoclonal antibodies, Surface Plasmon Resonance with spectral interrogation and Atomic Force Microscopy.
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