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Looking for a method to monitor #interactions involving #photosensitive proteins? Check out our front-illuminated surface plasmon resonance #biosensor (#fiSPR) and learn more about our article in collaboration with the @IBT_CAS .
https://www.sciencedirect.com/science/article/pii/S0956566325008747
Optical Biosensors
We pursue the research of biosensors – instruments for the detection of chemical and biological substances important for medical diagnostics, food safety or environmental protection, and for the study of biomolecules and biomolecular interactions in molecular biology and pharmaceutical research. We specialize primarily in optical biosensors that enable non-invasive, fast and sensitive analysis using special electromagnetic waves – surface plasmons.
We combine theoretical and experimental knowledge from several areas of physics, chemistry and biology. This multidisciplinary research includes a wide range of activities – from the research of photonic and plasmonic (nano)structures and functional biomolecular ensembles, through the development of optical measurement methods and systems, to their use for the study of biomolecular interactions and the detection of chemical and biological substances. We are engaged in the development of sophisticated laboratory systems and mobile biosensor solutions for use outside the laboratory.
Our biosensors enable direct study of biomolecular interactions in real time and without the use of labels. Using our biosensors, we aim to understand the biomolecular principles of biological processes, especially those related to the occurance and development of diseases. For example, we study cellular processes or biomolecular interactions relevant for neurodegenerative and cancer diseases.
Surface plasmons and surface plasmon-related phenomena on photonic (nano)structures
We carry out theoretical and experimental research to expand the understanding of optical phenomena in photonic (nano)structures, in particular, in (nano)structures supporting various types of surface plasmons, with a focus on their role in optical biosensing based on Surface Plasmon Resonance (SPR) and Surface-Enhanced Raman Scattering (SERS).
Functional biomolecular systems for affinity biosensors
We investigate approaches to interface inorganic photonic (nano)structures with biomolecules. Specifically, we look to control the placement of the biomolecules on the photonic (nano)structures, and furthermore, to optimize the properties of the photonic (nano)structures functionalized with biomolecules with respect to their interactions with biological media.
Microfluidics and transport phenomenon
We investigate microfluidic methods to improve the performance of optical biosensors, focusing on the design and optimization of low-cost and practical flow cells for everyday use. In this process we examine the interplay between the physics associated with the sensor design and the role of convection, diffusion, and chemical reactions.
Measurement methods and sensor instrumentation
We research optical measurement techniques, including measurement principles, instrumentation, and data processing approaches, to create optical systems for high-performance optical biosensors. We focus on the research and development of compact systems.
Measurement methods and sensor instrumentation
We research optical measurement techniques, including measurement principles, instrumentation, and data processing approaches, to create optical systems for high-performance optical biosensors. We focus on the research and development of compact systems.
Optical biosensors for investigation of biomolecules and their interactions
We pursue optical biosensor application for the study of biomolecules and their interactions, for example, interactions of nucleic acids, protein-protein interactions and studies of enzymatic activity. This effort comprises, in particular, the development of novel experimental methodologies and data analysis tools.
Optical biosensors for detection of chemical and biological substances
We develop novel biosensors for the rapid and sensitive detection of chemical and biological substances relevant to medical diagnostics (disease biomarkers), environmental monitoring (pollutants and contaminants), and food safety (pathogens and toxins).
